In a 9 months old, mixed breed calf an increase in size of the liver was noticed, it had a hardened consistency and multiple nodules separated by paler tissue.

Histopathological examination evidenced bile duct hyperplasia, and an evident increase of conjunctive tissue in portal spaces and in a mesh of fibrovascular septa that completely surrounded the hepatic lobuli. The nodules corresponded to islands of residual liver tissue regeneration. A morphological diagnosis of hepatic cirrhosis was established.

Cirrhosis is the final, irreversible, phase of various pathogenic processes leading to hepatocyte cell death (apoptosis or necrosis) and fibrosis with chronic active inflammation. Among these processes one can find intoxication and cirrhosis due to parasitic infestation.

Multiple nodular lesions separated by paler tissue.

Multiple nodular lesions separated by paler tissue.

View of the diaphragmatic surface of the liver.

View of the diaphragmatic surface of the liver.

The lesion can also be observed when the parenchyma is sectioned.

The lesion can also be observed when the parenchyma is sectioned.