Esplenomegalia e icterícia en canales de cerdo
En dos canales de cerdo de raza híbrida se observa una marcada ictericia y esplenomegalia. Macroscópicamente el hígado no presenta alteraciones.
El estudio histopatológico de las muestras de hígado y bazo revela que el hígado no presenta lesiones significativas, los cambios del bazo se deben a extensas áreas hemorrágicas. Se descartan lesiones de tipo inflamatorio-necróticas.
No se puede determinar la causa de estas hemorragias, pero muy probablemente se deben a una torsión esplénica o a traumatismos. La causa del ictericia y si tiene relación con la torsión esplénica es incierta. Una posibilidad sería que la degradación de los eritrocitos extravasados hubiera producido la ictericia, se trataría entonces de una ictericia prehepàtica por hemólisis.
Aumento del tamaño del bazo (50 cm x 20 cm) con cambios de coloración en la superficie. El hígado no presentaba alteraciones.
Los cambios de coloración amarillenta (ictericia) eran evidentes en el tejido adiposo pericárdico así como a la esclera, los endotelios y la pelvis renal.
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#2 escrito por SESC hace 7 añosComment form LinkedIn:
I don’t know about the pig . How about the protozoal diseases?
Thank to your slides.SESC’s pathologists answer is:
There are a number of pathogens that may cause jaundice in pigs, being the most usual one Mycoplasma (Eperythrozoon) suis. In that particular case, M. suis was not investigated, since just two pigs from the batch showed jaundice. Moreover, jaundice is usually linked to hepatic damage and/or hemolysis as the most common generic causes, but no presumable relationship with spleen necrosis has been described as far as we know. In pigs, to our knowledge, no protozoan parasites are known to cause jaundice.
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#3 escrito por SESC hace 7 años
Comment from LinkedIn:
Did you check these animals for Hep E virus?
Our pathologists answer:
We have no information about the status of infection with HEV in this pig. From our previous studies with HEV, many pigs in a herd become infected, in a totally subclinical way, even with no demonstrable lesions in the liver. The only way to rule out a HEV infection would be by PCR in liver tissue or in bile. We are not aware of a relationship between HEV and spleen lesions.
For further reference:
de Deus, N., Casas, M., Peralta, B., Nofrarias, M., Pina, S., Martin, M., Segales, J., 2008, Hepatitis E virus infection dynamics and organic distribution in naturally infected pigs in a farrow-to-finish farm. Vet Microbiol 132, 19-28.
de Deus, N., Seminati, C., Pina, S., Mateu, E., Martin, M., Segales, J., 2007, Detection of hepatitis E virus in liver, mesenteric lymph node, serum, bile and faeces of naturally infected pigs affected by different pathological conditions. Vet Microbiol 119, 105-114.
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#4 escrito por SESC hace 7 años
Comment from LinkedIn:
Nice pictures. This incidental finding did me remember an other spleen problem the spleen atrophy. Is the spleenmegaly resolvebel ( ?) and ending in an atrophy?
Our pathologists answer:
Thanks for your comment. After a spleen torsion, the probable evolution of the lesion would be to a ischemic necrosis of the spleen, and sequester formation. The spleen would not be functional anymore. In strict sense it would not be appropriate to speak about atrophy, as the organ is not involved in a progressive reduction of the tissular component.
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There are a number of pathogens that may cause jaundice in pigs, being the most usual one Mycoplasma (Eperythrozoon) suis. In that particular case, M. suis was not investigated, since just two pigs from the batch showed jaundice. Moreover, jaundice is usually linked to hepatic damage and/or hemolysis as the most common generic causes, but no presumable relationship with spleen necrosis has been described as far as we know. In pigs, to our knowledge, no protozoan parasites are known to cause jaundice.