Samples of rabbit livers have been submitted to SESC with multifocal whitish lesions.

This type of lesion can be associated with different causes, the first two are the most common:

 

CAUSE

PATHOLOGY

DIAGNOSTIC METHOD

Coccidiosis

(Eimeria Stiedae)

Hyperplasia and bile ducts fibrosis. Histopathology: microscopic observation of coccidia.

Stool Analysis.

Parasitic migration

(Taenia pisiformis)

Migration paths.

Granulomas.

Histopathology
Salmonellosis

(Salmonella typhymurium, Salmonella enteritidis)

Focal hepatic necrosis. Histopathology

Culture with special enrichment methods.

Tyzzer Disease

(Clostridium piliformis)

Focal hepatic necrosis. Histopathology

Warthin Starry staining.

Listeriosis

(Lysteria monocytogenes)

Focal hepatic necrosis. Histopathology

Bacterial culture.

Myxomatosis

Poxvirus

Focal hepatic necrosis. Histopathology
Mycobacterium Focal hepatic caseous necrosis. Histopathology Zhiel Neelsen staining.
Pseudotuberculosis

(Yersinia pseudotuberculosis)

Focal hepatic caseous necrosis. Histopathology

Bacterial culture.

Coronavirus Focal hepatic necrosis. Histopathology
Neoplasia

Lymphoma

Uterine carcinoma.

  Histopathology
Whitish multifocal lesions. Histopathology could not determine the cause. The microbiological culture was negative, even when pre-enrichment for Salmonella was used. Warthin Starry and  Ziehl Neelsen staining did not show the presence of Clostridia nor Mycobacteria. A RFLP study was conducted to detect the presence of pathogenic bacteria witha negative result. The chronic nature of the lesion may prevent the detection of the causative agent.

Whitish multifocal lesions. Histopathology could not determine the cause. The microbiological culture was negative, even when pre-enrichment for Salmonella was used. Warthin Starry and Ziehl Neelsen staining did not show the presence of Clostridia nor Mycobacteria. A RFLP study was conducted to detect the presence of pathogenic bacteria witha negative result. The chronic nature of the lesion may prevent the detection of the causative agent.

In this occasion the whitish lesions corresponded to hyperplasia and bile ducts fibrosis due to the presence of coccidia (Eimeria stiedae).

In this occasion the whitish lesions corresponded to hyperplasia and bile ducts fibrosis due to the presence of coccidia (Eimeria stiedae).

Photomicrograph of an Hematoxylin-eosin staining . Bile duct hyperplasia can be observed as well as periductal inflammation and  fibrosis (asterisk) and the presence of protozoal structures inside the ducts and the epithelium (arrows). Top left extended.

Photomicrograph of an Hematoxylin-eosin staining . Bile duct hyperplasia can be observed as well as periductal inflammation and fibrosis (asterisk) and the presence of protozoal structures inside the ducts and the epithelium (arrows). Top left extended.