At the end of the post you can vote for the right diagnosis!

We present on this occasion, images of two cases (1 and 2) of granulomatous lymphadenitis in cattle.
Also, you can see images (A and B) of the corresponding histopathological studies.
Finally, you need to relate each image with its histopathology and the diagnosis you believe is correct.

Good luck!

CASE 1:

CASE 1: Granulomatous lesions in the traqueo-bronchial lymph node of a 13 months old, male, cross breed calf. In the picture below you can see the sectioned lesion.

CASE 1: Granulomatous lesions in the traqueo-bronchial lymph node of a 13 months old, male, cross breed calf. In the picture below you can see the sectioned lesion.

CASE 2:

CASE 2: Granulomatous lesions in the lung parenchyma and mediastinal and retropharingeal  lymph nodes in a 10 months old, male, Friesian calf.

CASE 2: Granulomatous lesions in the lung parenchyma and mediastinal and retropharingeal lymph nodes in a 10 months old, male, Friesian calf.

HISTOPATHOLOGICAL STUDY A:

Histopathological study A: Presence of granulomatous inflammation with areas of necrosis, multinucleated giant cells and the structures pointed by the arrowheads (both in the  necrosis and inside cells).

Histopathological study A: Presence of granulomatous inflammation with areas of necrosis, multinucleated giant cells and the structures pointed by the arrowheads (both in the necrosis and inside cells).

HISTOPATHOLOGICAL STUDY B:

Histopathological study B: presence of granulomatous inflammation with areas of necrosis, multinucleated giant cells and the structures that the arrowhead points at.

Histopathological study B: presence of granulomatous inflammation with areas of necrosis, multinucleated giant cells and the structures that the arrowhead points at.

What is your diagnosis? (19)

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Case 1 corresponds to histopathological study A and the right diagnosis is fungal lymphadenitis since hyphae can be observed in necrotic areas and within the cytoplasm of multinucleated giant cells.

 

Case 2 corresponds to histopathological study B and to a diagnosis of tuberculosis. The typical granulomatous lesions, the presence of Langhans cells and the observation of acid alcohol resitant bacili at Ziehl Neelsen's staining confirm this diagnosis.

 

However, both lesions were, macroscopically, compatible with tuberculosis and thus it was necessary to submit samples for its laboratory confirmation.

 
Your answers are highlighted below.
Question 1
A
Case 1 Study B Nocardia / Case 2 Study A Verminous pneumonia
B
Case 1 Study B Tuberculosis / Case 2 Study A Actinomyces
C
Case 1 Study A Fungal lymphadenitis / Case 2 Study B Tuberculosis
D
Case 1 Study A Tuberculosis / Case 2 Study B Fungal Lymphadenitis
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