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In an eleven-month-old calf, of the Bruna dels pirineus breed, multiple whitish and hardened nodules are observed in the ventral aspect of the mucosa of the tongue.

Multiple hardened and whitish nodules (arrows) at the base of the tongue.

Microscopic appearance of one of the lesions


What is your diagnosis? (84)


This lesion, histologically, corresponds to a pyogranulomatous glossitis of bacterial etiology. In this enlarged image, we can see three components that help us establish this diagnosis: (1) Splendore hoeppli: central eosinophilic structure consisting of colonies of bacteria with radial deposition of immunocomplexes. Around it we can observe a (2) suppurative inflammatory infiltrate, consisting of neutrophilic polymorphonuclear leukocytes and, in the outermost part (3) the granulomatous component, consisting of clearer cytoplasmic macrophages. This lesion is compatible with an incipient stage of  Actinobacillus lignieresii infection or with an infection by other bacteria such as Nocardia, Trueperella, Actinomyces ... The other differentials included in this challenge can cause macroscopically similar lesions that are submitted to SESC to rule out Bovine Cysticercosis.

1: Splendore hoeppli. 2: Suppurative inflammatory infiltrate. 3: Granulomatous inflammatory infiltrate.

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Question 1
What is your diagnosis?
Bovine cysticercosis
Calcinosis cutis
Bacterial glossitis
Epithelial cysts
Peripheral nerve sheath tumour
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