On May 22-25, 2018 the international congress PRION 2018 took place in Santiago de Compostela, since its first edition in Paris in 2009, this congress brings together experts from all over the world in prions, it is a  multidisciplinary meeting that gathers from doctors to veterinarians through biochemists, biologists and bioinformatics who study the structure of the molecules to give a holistic approach to a problem that is far from having a solution: the diseases caused by protein misfolding.